Related Experiment Videos
PAI-1 in human hypertension: relation to hypertensive groups
Nadarajah Srikumar1, Nancy J Brown, Paul N Hopkins
1Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
American Journal of Hypertension
|August 6, 2002
Summary
Dietary salt restriction increased plasminogen activator inhibitor type-1 (PAI-1) levels in hypertensive patients. Aldosterone (ALDO) showed a significant correlation with PAI-1, suggesting its role in PAI-1 variability.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Metabolic Syndrome
Background:
- The renin-angiotensin system and insulin resistance (IR) are known regulators of plasminogen activator inhibitor type-1 (PAI-1).
- Their specific roles in hypertensive individuals remain unclear.
Purpose of the Study:
- To investigate the impact of dietary salt restriction on PAI-1 levels in hypertensive subjects.
- To explore the correlations between PAI-1, plasma renin activity (PRA), insulin resistance (IR), and aldosterone (ALDO).
Main Methods:
- 239 hypertensive subjects underwent dietary salt restriction (200 and 10 mmol/day).
- PAI-1 and PRA levels were measured. Fasting insulin, glucose, and ALDO were assessed on low-salt diet.
- Subjects were categorized into low renin, nonmodulators, and modulators groups.
Main Results:
- Sodium restriction significantly increased PAI-1 levels (P = .009).
- PAI-1 positively correlated with PRA, IR, triglycerides, and ALDO.
- Modulators group exhibited significantly higher PAI-1 levels compared to other groups.
Conclusions:
- PRA, IR, and ALDO are correlated with PAI-1 levels in hypertensive patients.
- Aldosterone may significantly contribute to individual variations in PAI-1 levels among hypertensive subjects.
Keywords:
Non-programmatic