Prostaglandin synthetase and prostaglandin E2 levels in human breast carcinoma

Prostaglandin synthetase activity and tissue prostaglandin E2 levels were measured in 53 human breast carcinoma specimens. Each set of data is log-normally distributed. There is a weak but statistically significant correlation between prostaglandin synthetase activity and tissue prostaglandin E2 levels of individual specimens. In addition, in a series of four rat mammary tumors, a rough correlation between prostaglandin synthetase activity and tissue prostaglandin E2 levels was observed. The data suggest a multifactorial explanation for abnormalities of prostaglandin metabolism in human breast cancer.