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Updated: Sep 30, 2026

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
Published on: September 20, 2019
Anergy and chemokine receptors
1Department of Paediatrics, Peter Lougheed Centre, Calgary, Canada.
Abstract:
The human immunodeficiency virus (HIV) induces a spectrum of immune abnormalities in the host by binding to CD4 molecules and chemokine receptors. Anergy, apoptosis, and immune activation are among the diverse immunological changes observed in the host. Chemokines, being the natural ligands for the chemokine receptors, block the entry of a retroviral strain, which exhibits tropism for the given receptor. This opens new therapeutic strategies and intervention possibilities for treating HIV-infected individuals.
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