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Anergy and chemokine receptors
1Department of Paediatrics, Peter Lougheed Centre, Calgary, Canada.
Medical Hypotheses
|August 6, 2002
Abstract:
The human immunodeficiency virus (HIV) induces a spectrum of immune abnormalities in the host by binding to CD4 molecules and chemokine receptors. Anergy, apoptosis, and immune activation are among the diverse immunological changes observed in the host. Chemokines, being the natural ligands for the chemokine receptors, block the entry of a retroviral strain, which exhibits tropism for the given receptor. This opens new therapeutic strategies and intervention possibilities for treating HIV-infected individuals.