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Updated: Sep 30, 2026

Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model
09:03

Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model

Published on: October 16, 2017

Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia virus insertions at Lvis22

Kathryn E Hentges1, Sujatha P Yarlagadda, Monica J Justice

  • 1Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

Genomics
|August 6, 2002
PubMed

Insights

Murine leukemia retroviruses cause cancer by integrating into mouse DNA. Researchers identified a common integration site on chromosome 15, revealing a gene crucial for B-cell development and tumor progression.

Area of Science:

  • Oncology
  • Genomics
  • Immunology

Background:

  • Murine leukemia retroviruses induce leukemia via somatic integration into the host genome.
  • Common retroviral integration sites suggest disruption of critical oncogenesis genes.
  • Identifying these genes aids understanding of lymphocyte development and cancer progression.

Purpose of the Study:

  • To analyze a common retroviral integration site on mouse chromosome 15.
  • To identify and characterize genes affected by retroviral insertion.
  • To explore the role of these genes in oncogenesis and lymphocyte development.

Main Methods:

  • Analysis of common retroviral integration sites in murine leukemia.
  • Genomic structure analysis of genes near the integration site on chromosome 15.
  • Utilizing current genome databases for gene identification.

Main Results:

  • A common retroviral integration site was identified on mouse chromosome 15.
  • Genomic analysis revealed three genes near the integration site.
  • One affected gene, Tnfrsf13c (Baffr), is a B-cell receptor involved in lymphocyte development.

Conclusions:

  • Retroviral integration site analysis is effective for identifying genes in oncogenesis.
  • Tnfrsf13c (Baffr) misexpression at the integration site impacts lymphocyte development and tumor progression.
  • Genome databases facilitate rapid identification of novel genes at proviral insertion sites, aiding functional assignment.

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