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In vivo active antimalarial isonitriles
Chandan Singh1, Naveen Chandra Srivastav, Sunil K Puri
1Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India. chandancdri@yahoo.com
Bioorganic & Medicinal Chemistry Letters
|August 6, 2002
Abstract:
Building on the lead from antimalarial isonitriles 1-4 of marine origin, several easily accessible synthetic isonitriles were assessed for their antimalarial activity against Plasmodium falciparum (in vitro) and multidrug resistant Plasmodium yoelii in Swiss mice model (in vivo). Isonitrile 11 has shown promising activity in both these assays.