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In vivo active antimalarial isonitriles.

Chandan Singh1, Naveen Chandra Srivastav, Sunil K Puri

  • 1Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India. chandancdri@yahoo.com

Bioorganic & Medicinal Chemistry Letters
|August 6, 2002
PubMed
Summary

Marine-derived antimalarial isonitriles inspired the synthesis of new compounds. Synthetic isonitrile 11 demonstrated significant antimalarial activity in both in vitro and in vivo models.

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Area of Science:

  • Medicinal Chemistry
  • Parasitology
  • Drug Discovery

Background:

  • Marine natural products serve as a source of novel antimalarial leads.
  • Isonitriles are a class of compounds with potential therapeutic applications.

Purpose of the Study:

  • To synthesize and evaluate novel isonitriles for antimalarial activity.
  • To identify potent synthetic antimalarial agents based on marine leads.

Main Methods:

  • In vitro antimalarial assays against Plasmodium falciparum.
  • In vivo antimalarial assays using a multidrug-resistant Plasmodium yoelii mouse model.

Main Results:

  • Several synthetic isonitriles were screened for antimalarial efficacy.
  • Isonitrile 11 exhibited promising antimalarial activity in both in vitro and in vivo evaluations.

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Conclusions:

  • Synthetic isonitriles represent a viable avenue for developing new antimalarial drugs.
  • Isonitrile 11 is a potential candidate for further antimalarial drug development.