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C-3 Amido-indole cannabinoid receptor modulators
John Hynes1, Katerina Leftheris, Hong Wu
1Discovery Chemistry, Bristol-Myers Squibb, Princeton, NJ 08543-4000, USA. john.hynes@bms.com
Bioorganic & Medicinal Chemistry Letters
|August 6, 2002
Abstract:
C-3 Amido-indoles were found to selectively bind to the CB2 receptor. SAR studies led to optimized compounds with excellent in vivo potency against LPS induced TNF-alpha release in murine models of cytokine production.
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