Related Experiment Videos
Quinoline-3-carbothioamides and related compounds as novel immunomodulating agents
Takashi Tojo1, Glen W Spears, Kiyoshi Tsuji
1Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd, 2-1-6, Kashima,Yodogawa-ku, Osaka, Japan.
Bioorganic & Medicinal Chemistry Letters
|August 6, 2002
Abstract:
A series of quinoline-3-carbothioamides and their analogues was prepared via four synthetic routes and evaluated for their antinephritic and immunomodulating activities. The optimal compound 9g strongly inhibited the T-cell independent antibody production in mice immunized with TNP-LPS and was highly effective in two nephritis models, namely chronic graft-versus-host disease and autoimmune MRL/l mice.