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Synthesis of cholesterol-carborane conjugate for targeted drug delivery
Bingqing Ji1, Gina Peacock, D Robert Lu
1Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, GA 30602, Athens, USA
Bioorganic & Medicinal Chemistry Letters
|August 6, 2002
Abstract:
The cholesterol-carborane conjugate has been designed and synthesized to selectively deliver boron to tumor cells by means of reconstituted low-density lipoprotein. The chemical stability and cytotoxicity of the new compound have been examined. Several methods have been evaluated for incorporation of the compound into LDL.