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Related Experiment Videos

Insulin regulates plasma ghrelin concentration.

Mohammed F Saad1, Basem Bernaba, Chii-Min Hwu

  • 1Division of Clinical Epidemiology and Preventive Medicine, UCLA School of Medicine, Los Angeles, California 90024, USA. msaad@mednet.ucla.edu

The Journal of Clinical Endocrinology and Metabolism
|August 6, 2002
PubMed
Summary

Insulin infusion significantly suppresses plasma ghrelin levels, a hormone influencing appetite and body weight. This study reveals insulin as a key regulator of ghrelin, impacting nutritional status and body weight control.

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Area of Science:

  • Endocrinology
  • Metabolism
  • Gastroenterology

Background:

  • Ghrelin, a gastric peptide, stimulates growth hormone and influences appetite and fat storage.
  • Plasma ghrelin levels are affected by nutritional status and play a role in regulating food intake and body weight.

Purpose of the Study:

  • To investigate the effect of insulin infusion on plasma ghrelin concentrations.
  • To determine if insulin modulates ghrelin levels in humans.

Main Methods:

  • Eight subjects received a 2-hour infusion of insulin while maintaining normal blood glucose levels (euglycemia).
  • Plasma insulin and ghrelin levels were measured before, during, and after the insulin infusion.

Main Results:

  • Insulin infusion caused a significant decrease in plasma ghrelin levels, with suppression observed during and after the infusion.

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  • The maximum suppression of ghrelin ranged from 19% to 64%, occurring approximately 90-135 minutes after starting the insulin infusion.
  • A consistent inverse relationship between insulin and ghrelin was observed across all subjects.

    • Conclusions:

    • Insulin acts as a physiological and dynamic modulator of plasma ghrelin.
    • Insulinemia may mediate the influence of nutritional status on ghrelin concentration, impacting appetite and body weight regulation.