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[Pharmacokinetics in the elderly].

F Péhourcq1, M Molimard

  • 1Département de Pharmacologie, CHU Pellegrin-Carreire, Bordeaux, France.

Revue Des Maladies Respiratoires
|August 6, 2002
PubMed
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Aging alters drug pharmacokinetics, primarily affecting absorption, distribution, metabolism, and elimination. Reduced drug clearance, especially renal clearance, is common in older adults, often requiring dosage adjustments to prevent adverse drug reactions.

Area of Science:

  • Gerontology
  • Pharmacology
  • Physiology

Context:

  • Aging is associated with physiological changes impacting drug pharmacokinetics.
  • These changes can occur independently of disease states.
  • Understanding these alterations is crucial for safe medication management in older adults.

Purpose:

  • To summarize the key pharmacokinetic changes associated with aging.
  • To highlight the implications of these changes for drug therapy in the elderly.
  • To emphasize the need for individualized dosage adjustments.

Summary:

  • Physiological changes during aging can significantly alter drug pharmacokinetics, affecting absorption, distribution, metabolism, and elimination.
  • Renal clearance consistently declines with age, leading to reduced drug clearance, particularly for renally excreted drugs.

Related Experiment Videos

  • Altered pharmacokinetics in the elderly may necessitate dosage modifications to avoid drug toxicity or therapeutic failure.

    • Impact:

    • Provides a foundation for adjusting drug dosages in geriatric populations.
    • Highlights the importance of considering age-related physiological changes in clinical practice.
    • Contributes to improving medication safety and efficacy in older individuals.