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Predictive factors and correlates for pain in postpoliomyelitis syndrome patients
Helen-Maria Vasiliadis1, Jean-Paul Collet, Stan Shapiro
1Department of Epidemiology and Biostatistics, Jewish General Hospital, McGill University, Montreal, Que, Canada.
Objective:
To identify predictive and associated factors for muscle and joint pain in postpoliomyelitis syndrome (PPS).
Design:
Cross-sectional study design.
Setting:
Postpolio clinics.
Participants:
Baseline data on 126 PPS patients entered into a multicentered clinical trial.
Interventions:
Not applicable.
Main Outcome Measures:
Adjusted odds ratios were computed by using logistic regression modeling. Patients with or without muscle or joint pain were compared with regard to predictors and associated factors.
Results:
In multivariate analyses for muscle pain, significant predictive and associated factors were female gender (P=.0006), longer duration of general fatigue (P=.019), and a lower score on the general health scale (P=.009) of the Medical Outcomes Study 36-Item Short-From Health Survey (SF-36). In multivariate analyses for joint pain, significant predictive and associated factors were female gender (P<.003), longer latency (duration of stability after polio; P=.008), younger age at interview (P<.002), greater weakness at acute polio (P<.07), weaker lower-extremity muscle strength (P<.04), and a lower SF-36 general health scale score (P<.02).
Conclusions:
Women are more likely to report muscle and joint pain in PPS. Greater initial motor unit involvement and lower-extremity weakness may be additional important factors for determining joint pain. Both muscle and joint pain are associated with reductions in quality of life.