Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Multiple sclerosis with childhood onset].

N A Totolian, A A Skoromets, T N Trofimova

    Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
    |August 7, 2002
    PubMed
    Summary

    Early-onset multiple sclerosis (MS) presents unique symptoms and poorer outcomes compared to adult-onset MS. Identifying specific biomarkers like kappa-free light chains in cerebrospinal fluid (CSF) can aid in early diagnosis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Analysis of the causes of late diagnosis of vascular myelopathy].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2025
    Same author

    [Diagnostic capabilities of spinal MR angiography and spinal MR tractography in a patient with motor neuron disease].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2023
    Same author

    [Neurological aspects of diagnosis and treatment of motor alalia].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2023
    Same author

    [Therapy of moderate cognitive impairment and asthenia in patients with cerebrovascular pathology: results of a prospective observational study].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2022
    Same author

    [Utility of spinal MRI tractography and spinal MRI angiography in the diagnosis of spastic diplegia].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2022
    Same author

    [Efficacy and safety of treatment with ampasse: the results of a randomized, double-blind, placebo-controlled trial in patients with chronic cerebrovascular disorders].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2021

    Area of Science:

    • Neurology
    • Immunology
    • Pediatrics

    Background:

    • Multiple sclerosis (MS) is a chronic neurological disease affecting adults and children.
    • Early-onset MS (before age 17) has distinct clinical and radiological features.
    • Understanding these differences is crucial for accurate diagnosis and management.

    Purpose of the Study:

    • To compare clinical manifestations, MRI findings, and immunological markers in early-onset MS versus adult-onset MS.
    • To identify potential diagnostic biomarkers for pediatric MS.
    • To elucidate the disease course and prognostic factors in early-onset MS.

    Main Methods:

    • Retrospective analysis of clinical data, MRI scans, and laboratory tests (blood and CSF).
    • Comparison of 19 early-onset MS patients with 100 adult-onset MS patients.

    Related Experiment Videos

  • Evaluation of immunological markers including albumin coefficient and free light chain concentrations.

    • Main Results:

    • Early-onset MS showed differences in sex ratio and initial symptoms, with higher rates of acute brainstem dysfunction and optic neuritis.
    • Tumor-like inflammatory lesions on MRI were more common in early-onset MS (29%).
    • Increased hematoencephalic barrier dysfunction (100% vs 50%) and elevated CSF kappa-free light chains (86% vs 99%) were observed in early-onset MS, confirming diagnostic value.

    Conclusions:

    • Early-onset MS exhibits distinct clinical and radiological characteristics, often with a more severe disease course.
    • Elevated kappa-free light chains in CSF are a valuable diagnostic marker for both early and adult-onset MS.
    • These findings can improve the diagnostic accuracy of MS in children.