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Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
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Secondary Lymphoid Organs01:15

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
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Related Experiment Video

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Peripheral T-cell lymphoma.

Wing Y Au1, Raymond Liang

  • 1University Department of Medicine, Queen Mary Hospital, 4/F Professorial Block, Pokfulam Road, Hong Kong SAR, China. auwing@hotmail.com

Current Oncology Reports
|August 7, 2002
PubMed
Summary

Accurate classification of peripheral T-cell lymphomas is crucial for treatment. The World Health Organization (WHO) classification refines understanding of these diverse T-cell and natural killer (NK)-cell lymphomas.

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Peripheral (post-thymic) T-cell lymphomas (PTCLs) are a heterogeneous group of lymphoid malignancies.
  • Historically, PTCL studies often lacked specific diagnostic criteria, hindering accurate interpretation of treatment outcomes.
  • Advances in immunophenotyping and molecular diagnostics have led to improved classification systems.

Purpose of the Study:

  • To review the current classification of post-thymic T/natural killer (NK)-cell lymphomas.
  • To highlight the importance of accurate pathological diagnosis for treatment and prognosis.
  • To discuss the varying incidence, viral associations, and treatment strategies for different PTCL entities.

Main Methods:

  • Review of existing literature and classification systems, including the Revised European-American Lymphoma (REAL) and World Health Organization (WHO) classifications.

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  • Analysis of diagnostic criteria, epidemiological data, and treatment outcomes for various PTCL subtypes.
  • Discussion of emerging therapeutic modalities.

    • Main Results:

    • The WHO classification delineates 15 distinct entities of post-thymic T/NK-cell lymphoma, with approximately 30% remaining unclassified.
    • Incidence varies significantly across populations, with certain subtypes showing strong racial predilection and viral associations (e.g., HTLV-1).
    • Prognosis and treatment efficacy differ among PTCLs, with aggressive chemotherapy effective for some (e.g., ALK-positive anaplastic lymphoma kinase), and purine analogs for others.

    Conclusions:

    • Accurate pathological diagnosis based on WHO classification is essential for effective management of PTCLs.
    • Treatment strategies must be individualized according to specific diagnosis and prognostic factors.
    • Further research is needed to define the role of stem cell transplantation and novel therapies like antibody-based treatments.