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Updated: Aug 12, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
Published on: September 12, 2016
Successful immune treatment for non-paraneoplastic limbic encephalitis
Masahiro Mori1, Satoshi Kuwabara, Mitsuharu Yoshiyama
1Department of Neurology, Chiba University School of Medicine, 1-8-1, Inohana, Chuo-ku, 260-8670, Chiba, Japan. morim@olive.ocn.ne.jp
Abstract:
A 21-year-old woman subacutely developed memory loss subsequent to gastroenteritis. Brain MRI with gadolinium enhancement showed symmetric involvement of the amygdala. The CSF was acellular with increased protein level. There was no evidence suggestive of neoplasm or viral infection. Combined treatment with plasmapheresis and immunoglobulin improved her clinical symptoms and lessened abnormalities manifested in the MRI. This case suggests the presence of immune-mediated limbic encephalitis without association with neoplasms or infections.
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