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Updated: Aug 14, 2026

Dissection and Coronal Slice Preparation of Developing Mouse Pituitary Gland
Published on: November 16, 2017
Growth hormone-releasing hormone and pituitary development, hyperplasia and tumorigenesis
Lawrence A Frohman1, Rhonda D Kineman
1Section of Endocrinology, Dept of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. frohman@uic.edu
Abstract:
Growth hormone-releasing hormone (GHRH) is essential for expansion of the somatotrope lineage during pituitary development, and excessive GHRH secretion and/or action results in unregulated somatotrope proliferation and neoplastic transformation. Our understanding of the molecular and morphological bases for these effects from both animal and clinical studies has greatly increased during the past decade. However, many features of the cellular pathways remain to be defined, including the interaction of other genes in the multistep process of somatotrope tumorigenesis.
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