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Decelerating decay of latently infected cells during prolonged therapy for human immunodeficiency virus type 1
Viktor Müller1, Javier Flavio Vigueras-Gómez, Sebastian Bonhoeffer
1Ecology and Evolution, ETH Zürich, 8092 Zürich, Switzerland. mueller@eco.umnw.ethz.ch
Journal of Virology
|August 7, 2002
Abstract:
Antiviral therapy induces a rapid drop in human immunodeficiency virus type 1 viremia, but the decline of virus levels decelerates over time. Mathematical modeling demonstrates that the source of residual virus production might be a single compartment of latently infected cells with an extended distribution of activation rates.