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The vaccinia virus I7L gene product is the core protein proteinase
Chelsea M Byrd1, Tove' C Bolken, Dennis E Hruby
1Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331, USA.
Journal of Virology
|August 7, 2002
Abstract:
Maturation of vaccinia virus (VV) core proteins is required for the production of infectious virions. The VV G1L and I7L gene products are the leading candidates for the viral core protein proteinase (vCPP). Using transient-expression assays, data were obtained to demonstrate that the I7L gene product and its encoded cysteine proteinase activity are responsible for vCPP activity.