Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Correlation between PET and SISCOM in temporal lobe epilepsy.

Viviane Bouilleret1, M Paola Valenti, Edouard Hirsch

  • 1Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Orsay, France.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|August 7, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seizure-related biomarkers of sudden unexpected death in epilepsy (SUDEP) in drug-resistant focal epilepsy (REPO<sub>2</sub>MSE): a prospective, multicentre case-control study.

The Lancet. Neurology·2025
Same author

Electroencephalogram in children with hepatic encephalopathy: towards a new classification?

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2025
Same author

Imaging P-glycoprotein function at the blood-brain barrier in drug-resistant epilepsy using [<sup>11</sup>C]metoclopramide.

European journal of nuclear medicine and molecular imaging·2025
Same author

Efficacy of naloxone in reducing hypoxemia and duration of immobility following focal to bilateral tonic-clonic seizures.

Epilepsia open·2025
Same author

Explosive onset focal epilepsies without cortical malformation: A review of a pediatric cohort with pathogenic variations in the GATOR1 complex (DEPDC5, NPRL3 and NPRL2).

Seizure·2025
Same author

Real-world effectiveness and tolerability of cenobamate in drug-resistant epilepsy: A retrospective analysis of the patients included into the Early Access Programs (EAP) in Germany, France, and United Kingdom.

Epilepsia open·2025

Subtraction of interictal from ictal SPECT coregistered to 3D MRI (SISCOM) and (18)F-FDG PET show high concordance in defining the epileptogenic zone in temporal lobe epilepsy (TLE). Both techniques help identify seizure generation and spread in metabolically abnormal regions.

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Epilepsy Research

Background:

  • Refractory partial temporal lobe epilepsy (TLE) requires accurate definition of the epileptogenic zone for effective treatment.
  • Subtraction of interictal from ictal SPECT coregistered to 3D MRI (SISCOM) and (18)F-FDG PET are key neuroimaging techniques for this purpose.

Purpose of the Study:

  • To compare, region by region, the functional patterns identified by SISCOM and (18)F-FDG PET in patients with unilateral TLE.
  • To assess the concordance and discrepancies between these two imaging modalities in defining the epileptogenic zone.

Main Methods:

  • Acquisition of perfusion data using SISCOM and metabolic data using (18)F-FDG PET in 17 patients with unilateral TLE.
  • Coregistration of functional imaging data (SISCOM and PET) with 3D anatomical MRI scans for precise spatial localization.

Related Experiment Videos

Main Results:

  • High concordance was observed between SISCOM and (18)F-FDG PET findings, primarily in the temporal lobes, orbitofrontal, and insular cortices.
  • Discrepancies included PET identifying more abnormalities in mesial and anterior neocortical regions, while SISCOM showed more abnormalities in posterior temporal neocortex and extratemporal cortex.
  • Functional patterns from both techniques were mainly located in ipsilateral and contralateral temporal lobes.

Conclusions:

  • The high concordance between PET and SISCOM abnormalities supports their combined utility in understanding seizure generation and spread in TLE.
  • Seizures in TLE appear to originate and propagate within regions exhibiting both metabolic and perfusion abnormalities.
  • These findings aid in refining the definition of the epileptogenic zone in refractory TLE.