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Sequential H(2)(15)O PET studies in baboons: before and after amphetamine.

Julie C Price1, Wayne C Drevets, James Ruszkiewicz

  • 1Department of Radiology, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA. price@pet.upmc.edu

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|August 7, 2002
PubMed
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This study investigated how d-amphetamine (AMPH) affects cerebral blood flow (CBF) during Positron Emission Tomography (PET) scans. Findings suggest CBF changes are unlikely to significantly impact dopamine activity measurements using (11)C-raclopride.

Area of Science:

  • Neuroscience
  • Radiochemistry
  • Pharmacology

Background:

  • Positron Emission Tomography (PET) with (11)C-raclopride is used to measure dopamine activity.
  • This method relies on d-amphetamine (AMPH) to induce dopamine release.
  • A key assumption is that cerebral blood flow (CBF) remains constant during PET scans.

Purpose of the Study:

  • To evaluate the impact of AMPH administration on sequential PET measurements of CBF.
  • To determine if CBF variations affect the accuracy of dopamine activity assessment.

Main Methods:

  • Six baboons underwent dynamic H(2)(15)O PET scans before and after AMPH administration (0.6 mg/kg).
  • Arterial blood sampling and MRI-defined regions of interest (cortex, striatum, cerebellum) were used.
  • CBF was quantified using a 1-tissue compartment model (K(1)).

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Main Results:

  • AMPH administration induced transient increases in CBF (K(1)) across various brain regions in most baboons.
  • These CBF alterations, though statistically significant in some areas, were deemed unlikely to substantially affect (11)C-raclopride binding potential.
  • Anesthesia-induced variability was minimized to enhance in vivo measure reliability.

Conclusions:

  • The study supports the assumption of stable CBF in (11)C-raclopride/AMPH PET experiments.
  • It highlights the necessity of accounting for anesthesia effects when interpreting in vivo imaging parameters.
  • Results validate prior PET studies assuming constant blood flow.