Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene-nutrient interactions and DNA methylation.

Simonetta Friso1, Sang-Woon Choi

  • 1Vitamin Metabolism Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. sfriso@hnrc.tufts.edu

The Journal of Nutrition
|August 7, 2002
PubMed
Summary

Folate is crucial for DNA health and methylation. Low folate impairs DNA, especially with genetic factors, impacting gene expression and disease risk.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lipoprotein(a) plasma levels and coagulation biomarkers: Results from a comprehensive laboratory assessment in an angiographically controlled cardiovascular cohort.

Journal of clinical lipidology·2026
Same author

Update on Vitamin D Status and Seasonal Variation in a Non-Supplemented Population Living in a High Polluted Urban Area-A Cross-Sectional Study.

Nutrients·2026
Same author

Medial arterial calcification and refractory osteomyelitis in systemic sclerosis: a case report and literature review.

Internal and emergency medicine·2026
Same author

Trends of T2 and Non-T2 Cytokines During Mepolizumab Treatment in Different Asthma Patient Subgroups.

Biomedicines·2026
Same author

Correction: Castagna et al. Sodium Chloride Cotransporter in Hypertension. <i>Biomedicines</i> 2024, <i>12</i>, 2580.

Biomedicines·2026
Same author

A case of VEXAS syndrome presenting as macrophage activation syndrome: from chronic inflammation to multi-organ failure.

Internal and emergency medicine·2026

Area of Science:

  • Nutritional Biochemistry
  • Epigenetics
  • Molecular Biology

Background:

  • Micronutrients and vitamins are essential for DNA synthesis, repair, and methylation.
  • Folate plays a unique role as a methyl donor in nucleotide synthesis and biological methylation.
  • Folate deficiency disrupts DNA and alters DNA methylation patterns, as shown in cell, animal, and human studies.

Purpose of the Study:

  • To investigate the role of folate in DNA metabolism and methylation.
  • To explore the impact of folate deficiency on DNA integrity and epigenetic patterns.
  • To examine the interaction between folate status, genetic polymorphisms, and DNA methylation in modulating gene expression.

Main Methods:

  • Review of cell culture, animal, and human studies on folate deficiency.
  • Analysis of methyl deficiency models to establish cause-and-effect relationships.
  • Investigation of the interaction between folate status and methylenetetrahydrofolate reductase (MTHFR) gene mutation.

Main Results:

  • Folate deficiency leads to DNA disruption and altered DNA methylation.
  • Methyl deficiency models show a stronger link between folate status and DNA damage.
  • An interaction between folate status and MTHFR polymorphism influences genomic DNA methylation.
  • Nutrient-gene interactions can modulate gene expression via DNA methylation.

Conclusions:

  • Impaired methyl supply due to inadequate folate status significantly affects DNA metabolism.
  • The interplay between nutritional status (folate) and genetic variations (MTHFR) impacts gene expression through DNA methylation.
  • Understanding nutrient-DNA methylation interactions is key for explaining disease pathophysiology and developing preventive strategies.

Related Experiment Videos