Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epigenetic variation and human disease.

Jean-Pierre Issa1

  • 1Department of Leukemia, The University of Texas at M.D. Anderson Cancer Center, Houston 77030, USA. jpissa@mdanderson.org

The Journal of Nutrition
|August 7, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A phase 1 study of ASTX727 plus talazoparib in patients with triple-negative or hormone resistant/HER2-negative metastatic breast cancer.

Cancer·2026
Same author

CDK9 degradation Inhibits Gastroesophageal Cancer growth and Overcomes Radiation Resistance by Increasing Chromatin Accessibility and Downregulating YAP1/TEAD signaling.

bioRxiv : the preprint server for biology·2025
Same author

ZNFX1 is a Novel Master Regulator in Epigenetically-induced Pathogen Mimicry and Inflammasome Signaling in Cancer.

bioRxiv : the preprint server for biology·2024
Same author

Tissue-infiltrating alloreactive T cells require Id3 to deflect PD-1-mediated immune suppression during GVHD.

Blood·2023
Same author

TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype.

Gastroenterology·2023
Same author

Safety, Outcomes, and T-Cell Characteristics in Patients with Relapsed or Refractory MDS or CMML Treated with Atezolizumab in Combination with Guadecitabine.

Clinical cancer research : an official journal of the American Association for Cancer Research·2022
Same journal

Evaluation of Energy and Nutrient Estimates from Large Language Models Using Text-Based Queries.

The Journal of nutrition·2026
Same journal

Considerations for Dietary Supplements After GLP-1RA Treatment: A Narrative Review.

The Journal of nutrition·2026
Same journal

The apple(juice) doesn't fall far from the tree: Children's hydration mirrors their parent's.

The Journal of nutrition·2026
Same journal

Microbial-derived polyphenol metabolites and the gut microbiota: A scoping review of clinical studies.

The Journal of nutrition·2026
Same journal

Hesperidin as an Emerging Nutraceutical in Modern Health and Preventive Medicine: A Narrative Review.

The Journal of nutrition·2026
Same journal

Short-Chain Fatty Acids in Livestock and Aquatic Animals: Metabolic Divergence, Physiological Functions, and Product Development.

The Journal of nutrition·2026
See all related articles

Epigenetic changes, specifically cytosine guanine dinucleotide (CpG) island methylation, increase with age and inflammation. This epigenetic variation influences disease risk and severity, highlighting its role in age-related conditions.

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Genomics

Background:

  • Cytosine guanine dinucleotide (CpG) island methylation is a key epigenetic mechanism in postmeiotic cells.
  • Epigenetic states influence cellular physiology, disease risk, and severity through chromatin changes and gene silencing.

Purpose of the Study:

  • To investigate age-related changes in CpG island methylation in normal colorectal mucosa.
  • To explore the impact of chronic inflammatory states on CpG island methylation.
  • To identify potential modulators of epigenetic variation, including lifestyle and environmental factors.

Main Methods:

  • Analysis of CpG island methylation in normal colorectal mucosa across different ages.
  • Examination of CpG island methylation in tissues affected by ulcerative colitis, hepatocellular cirrhosis, and neoplasia.

Related Experiment Videos

  • Assessment of preliminary data on lifestyle and exposure factors.

    • Main Results:

    • Progressive, age-related increases in CpG island methylation were observed at multiple gene loci in normal colorectal mucosa.
    • Significant increases in CpG island methylation were found in normal-appearing tissues associated with chronic inflammatory conditions.
    • Considerable inter-individual variation in methylation levels was noted, suggesting contributions from genetic, lifestyle, or environmental factors.

    Conclusions:

    • Epigenetic variation, driven by aging, inflammation, lifestyle, and genetic factors, plays a role in modulating age-related diseases, including neoplasia.
    • Proinflammatory exposures are a significant contributor to epigenetic variation in human populations.
    • CpG island methylation is a dynamic epigenetic mark influenced by multiple factors relevant to human health and disease.