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Related Experiment Videos

DNA Methylation Database "MethDB": a user guide.

Christoph Grunau1, Eric Renault, Gérard Roizes

  • 1Laboratoire de Séquences Répétées et Centromères Humains, Institut de Génétique Humaine, Montpellier, France. christoph.grunau@methdb.de

The Journal of Nutrition
|August 7, 2002
PubMed
Summary
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The DNA Methylation Database (MethDB) centralizes DNA methylation data, offering diverse search options for methylation patterns and content. This public resource invites scientific community contributions to expand its valuable dataset.

Area of Science:

  • Genomics
  • Epigenetics
  • Bioinformatics

Background:

  • DNA methylation is a crucial epigenetic mechanism influencing gene expression.
  • A centralized repository for DNA methylation data is needed for comprehensive research.
  • Existing data is fragmented across various sources, hindering accessibility.

Purpose of the Study:

  • To establish a public, comprehensive database for DNA methylation data.
  • To provide versatile search functionalities for DNA methylation profiles and content.
  • To facilitate data submission from the scientific community.

Main Methods:

  • Development of the DNA Methylation Database (MethDB) website.
  • Implementation of search features for browsing, sequence-specific queries, and environmental factors.

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  • Data curation and integration from various sources.

    • Main Results:

    • MethDB currently hosts 2570 methylation content values and 5278 methylation patterns/profiles for 83 genes/loci.
    • The database supports detailed queries on sequence-specific methylation, total content, and environmental influences.
    • MethDB is annotated and open for community data submissions.

    Conclusions:

    • MethDB serves as a valuable, centralized resource for DNA methylation research.
    • The database enhances accessibility and analysis of epigenetic data.
    • Community participation is encouraged to ensure the continued growth and utility of MethDB.