[Toxic effect of antituberculous drugs on spermatogenesis]

To determine the impact of multidrug therapy on male sexual function, isoniazid was tested for their effects on spermatogenesis and the liver in an experiment on laboratory animals, then on spermatogenesis and spermatozoidal function by using the clinical data. There is evidence for that isoniazid given to mice produces no toxic effect on spermatogenesis. The drug in a dose of 0.5% fails to affect the mobility of spermatozoa in vitro. Combined antituberculous therapy does not cause any significant changes in the basic indices of a spermatogram in patients with different forms of tuberculosis. Intermittent combined antituberculous therapy does not result in the derangement of major constituents of a copulative act.