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Theoretical modeling of oral absorption of barbiturates
Taravat Ghafourian1, Mohammad Barzegar-Jalali
1School of Pharmacy, Tabriz Medical Sciences University, Iran. ghafourt@tbzmed.ac.ir
Farmaco (Societa Chimica Italiana : 1989)
|August 8, 2002
Abstract:
The structural characteristics governing gastric absorption of barbiturates were studied using QSAR methodology. The results showed that the gastric absorption rate constant could be modeled using the theoretical parameters, accessible surface area, atomic charges and electrostatic potentials. Using molecular connectivity indexes was also satisfactory in modeling the absorption.