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Published on: April 5, 2011
Investigation of QT-interval dispersion in the electrocardiogram of 81 dogs
S G Dennis1, N J Summerfield, A Boswood
1Section of Cardiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia 19104-6010, USA.
Insights
This study established normal QT interval dispersion (QT dispersion) ranges in dogs, finding no significant difference in dogs with cardiac disease. Further research is needed due to potential measurement errors.
Area of Science:
- Veterinary Cardiology
- Electrophysiology
- Cardiac Diagnostics
Background:
- QT interval dispersion (QT dispersion) indicates ventricular repolarization inhomogeneity.
- Increased QT dispersion is linked to sudden death and arrhythmias in human cardiac diseases.
- QT dispersion has not been evaluated in canine populations.
Purpose of the Study:
- To establish a normal reference range for QT dispersion in dogs.
- To assess the impact of cardiac disease on QT dispersion in dogs.
Main Methods:
- Ten-lead electrocardiograms (ECGs) were recorded from 81 dogs across two veterinary hospitals.
- Data from 68 dogs (32 normal, 36 with cardiac disease) were analyzed.
- QT dispersion and heart rate-corrected QT dispersion were calculated.
Main Results:
- The mean QT dispersion was 20.8 (18.2 ms).
- The mean heart rate-corrected QT dispersion was 26.1 (23.6 ms).
- No significant effect of cardiac disease on QT dispersion was observed.
Conclusions:
- This study provides initial reference values for canine QT dispersion.
- Cardiac disease did not significantly alter QT dispersion in this cohort.
- Potential measurement errors necessitate cautious interpretation and further validation.
Abstract:
QT-interval dispersion (QT dispersion) is a marker of the inhomogeneity of ventricular repolarisation. In human beings an increase in QT dispersion has been linked to sudden death and arrhythmias in several cardiac diseases. In dogs it has yet to be evaluated, and this study aimed to establish a normal reference range for QT dispersion and to assess the effects of cardiac disease upon it. Ten-lead ECGS were recorded from 81 dogs at two hospitals; satisfactory traces were obtained from 68 dogs, 32 of them normal and 36 with cardiac disease. The mean (sd) QT dispersion was 20.8 (18.2 ms) and the mean heart rate-corrected QT dispersion was 26.1 (23.6 ms). There was no significant effect of cardiac disease. The accuracy of the results may be questioned owing to the identification of several potential errors in the measurements.
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