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Prognosis of primary melanoma
S Ilmonen1, S Asko-Seljavaara, A L Kariniemi
1Department of Plastic Surgery, Helsinki University Hospital, Finland. suvi.ilmonen@hus.fi
Summary
Prognosis for primary melanoma patients in Finland has improved. Key survival factors include tumor stage, thickness, invasion depth, ulceration, and patient age.
Area of Science:
- Oncology
- Dermatology
- Epidemiology
Background:
- Melanoma prognosis is influenced by various clinical and pathological factors.
- Understanding prognostic indicators is crucial for effective patient management and treatment strategies.
Purpose of the Study:
- To investigate the prognostic factors and survival rates of primary melanoma patients in Finland.
- To identify independent predictors of disease-free and overall survival in a Finnish cohort.
Main Methods:
- Retrospective study of 298 primary melanoma patients in Finland, predominantly with stage I or II tumors.
- Clinical follow-up data collected from patient records and survival data from national registries.
- Statistical analysis including univariate and multivariate Cox regression models.
Main Results:
- Overall survival rate was 66.8%. Significant prognostic factors included tumor stage, thickness, invasion depth, and ulceration.
- Tumor ulceration and trunk location were unfavorable prognostic markers. Younger patients had better survival.
- Tumor stage and thickness were independent predictors of survival in multivariate analysis.
Conclusions:
- The prognosis of primary melanoma in Finland has improved over recent decades.
- This improvement aligns with a global trend in melanoma outcomes.
- Early detection and appropriate management remain critical for improving melanoma survival rates.