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Allergic Reactions

Allergic Reactions

Allergic Reactions: Anaphylaxis

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

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Related Experiment Video

Updated: Jun 3, 2026

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Rodent allergens.

Wanda Phipatanakul¹

¹Children's Hospital, Harvard Medical School, Immunology, Fegan 6, 300 Longwood Avenue, Boston, MA 02115, USA. wanda.phipatanakul@tch.harvard.edu

Current Allergy and Asthma Reports

|August 8, 2002

Summary

This summary is machine-generated.

Rodent allergens from mice and rats are significant triggers for asthma and allergic rhinitis. Awareness is growing regarding their impact in homes, especially for children, necessitating better diagnosis and management.

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Area of Science:

Allergy and Immunology
Environmental Health

Background:

Rodent allergens are established causes of asthma and allergic rhinitis, particularly in occupational settings like laboratories.
Recent research highlights the significance of rodent allergens in home environments, especially for inner-city children with asthma.
The increasing popularity of rodents as pets contributes to heightened exposure and potential hypersensitivity.

Purpose of the Study:

To review the importance of rodent allergens, focusing on common species like mice and rats.
To discuss the role of other rodents such as gerbils, hamsters, and rabbits.
To cover the pathogenesis, diagnosis, prevention, and management of rodent allergy.

Main Methods:

This is a review article, synthesizing existing research and clinical knowledge.
Focuses on literature concerning mouse, rat, gerbil, hamster, and rabbit allergens.
Includes information on clinical presentation, diagnostic methods, and therapeutic strategies.

Main Results:

Rodent allergens are potent triggers for allergic respiratory diseases.
Exposure is relevant in both occupational and domestic settings.
Inner-city children with asthma may be particularly susceptible.

Conclusions:

Rodent allergy is an increasingly recognized health concern due to widespread exposure.
Comprehensive understanding of pathogenesis, diagnosis, and management is crucial.
Preventive measures and effective treatment strategies are needed to mitigate symptoms.