Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuronal calcium-binding proteins and schizophrenia.

D W Eyles1, J J McGrath, G P Reynolds

  • 1Queensland Centre for Schizophrenia Research, Wolston Park Hospital, Wacol, Q4076, Australia. Eyles@plpk.uq.edu.au

Schizophrenia Research
|August 8, 2002
PubMed
Summary

Calcium-binding proteins (CBPs) are key markers for GABAergic interneurons in brain regions affected by schizophrenia. Alterations in these proteins suggest a role in schizophrenia

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"Intranasal clozapine sol-gel formulation induces an antipsychotic effect at a fraction of a comparable oral therapeutic dose".

Translational psychiatry·2026
Same author

MC4R methylation and antipsychotic-related metabolic changes in early psychosis: findings from two prospective cohorts.

Schizophrenia research·2026
Same author

The cost of mental disorders: a systematic review.

Epidemiology and psychiatric sciences·2020
Same author

Comorbidity within mental disorders: a comprehensive analysis based on 145 990 survey respondents from 27 countries.

Epidemiology and psychiatric sciences·2020
Same author

Disentangling schizophrenia spectrum disorders.

Acta psychiatrica Scandinavica·2018
Same author

Smokin' hot: adolescent smoking and the risk of psychosis.

Acta psychiatrica Scandinavica·2018

Area of Science:

  • Neuroscience
  • Cell Biology
  • Psychiatry

Background:

  • Calcium-binding proteins (CBPs) like calbindin, parvalbumin, and calretinin serve as immunohistochemical markers for specific neuronal subpopulations.
  • These CBPs are crucial for identifying GABAergic interneurons, which regulate output in the prefrontal cortex, cingulate cortex, and hippocampus.
  • These brain regions and their interneurons are critical in neuropathological investigations of schizophrenia.

Purpose of the Study:

  • To review the functional properties of Calcium-binding proteins (CBPs).
  • To examine the emerging literature on alterations of CBPs in schizophrenia.
  • To discuss the significance of these findings in the context of schizophrenia pathophysiology.

Main Methods:

  • Literature review of immunohistochemical studies.

Related Experiment Videos

  • Analysis of neuropathological reports in schizophrenia patients.
  • Examination of functional properties of CBPs in neuronal survival and firing.

    • Main Results:

    • Growing number of reports indicate subtle changes in CBP-containing interneurons in schizophrenia patients.
    • CBPs provide survival advantages to neurons and enhance their sustained firing capacity.
    • These functional properties may be relevant to the pathophysiology of nondegenerative disorders like schizophrenia.

    Conclusions:

    • CBPs are more than just neuronal markers; they possess functional roles.
    • Alterations in CBPs in specific interneuron populations are increasingly linked to schizophrenia.
    • Further research into CBP function is warranted to understand their significance in schizophrenia.