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Cerebral cortex lesions decrease the number of bromodeoxyuridine-positive subventricular zone cells in mice.

Gwendolyn E Goings1, Bernadeta L Wibisono, Francis G Szele

  • 1CMIER Neurobiology Program, Children's Memorial Hospital, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, 2430 N. Halsted, No. 209, Chicago, IL 60614-3394, USA.

Neuroscience Letters
|August 8, 2002
PubMed
Summary
This summary is machine-generated.

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Cortical lesions in mice rapidly alter subventricular zone (SVZ) cell proliferation and neuroblast markers. These findings reveal species-specific SVZ responses to brain injury.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Previous studies demonstrated that cortical lesions increase subventricular zone (SVZ) cell numbers in rats.
  • The subventricular zone is a key area for neural stem cell proliferation and neurogenesis in the adult brain.

Purpose of the Study:

  • To investigate the temporal response of the mouse SVZ to cortical lesions.
  • To compare the mouse SVZ response to previously observed responses in rats.

Main Methods:

  • Induction of cortical lesions in mice.
  • Analysis of SVZ cell populations at various time points post-lesion (6 hours to 35 days).
  • Assessment of cell proliferation using bromodeoxyuridine (BrdU) incorporation and neuroblast markers via immunoreactivity for polysialylated neural cell adhesion molecule (PSA-NCAM).

Related Experiment Videos

Main Results:

  • No significant change in the total number of SVZ cells was observed.
  • A biphasic decrease in the number of cells in S-phase (proliferating cells) occurred at early (6 hours to 3 days) and late (25-35 days) time points.
  • A delayed increase in PSA-NCAM immunoreactivity, indicating an increase in neuroblasts, was noted between days 25 and 35 post-lesion.

Conclusions:

  • The mouse SVZ exhibits both rapid and delayed cellular responses following cortical injury.
  • These findings highlight significant species-specific differences in the mammalian SVZ response to similar brain injuries, contrasting with rat models.