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Human Meissner corpuscles express Bcl-2 but not Bax protein
José A Ortiz-Rey1, Carlos Alvarez-Alvarez, Iosu Antón-Badiola
1Department of Pathology, POVISA Centro Médico, Vigo (Pontevedra), Spain. jaortiz@povisa.es
Neuroscience Letters
|August 8, 2002
Abstract:
Bcl-2 and Bax proteins play major roles in the control of apoptosis. The Bcl-2/Bax ratio is considered a marker of a cell's susceptibility to apoptotic stimuli. Immunohistochemical expression of Bcl-2 and Bax in Meissner corpuscles was investigated in 30 human skin samples. All of the Meissner corpuscles showed immunoreactivity for Bcl-2 and Bax was negative. These data support a role for Bcl-2 as a resistance mechanism of these mechanoreceptors to apoptosis.