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Cell proliferation and chromosomal changes in human ameloblastoma
Karoliina Jääskeläinen1, Kowan J Jee, Ilmo Leivo
1Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku, Lemminkäisenkatu 2, FIN-20520, Turku, Finland.
Cancer Genetics and Cytogenetics
|August 8, 2002
Summary
Cell proliferation markers like MIB-1 index and chromosomal imbalances are uncommon in ameloblastoma, a benign odontogenic tumor. These factors do not reliably predict the tumor
Area of Science:
- Oral Pathology
- Oncology
- Genetics
Background:
- Ameloblastoma is a benign odontogenic tumor known for local recurrence.
- Tumor progression is often linked to cell proliferation and chromosomal abnormalities.
Purpose of the Study:
- To investigate cell proliferation using MIB-1 index and chromosomal imbalances via comparative genomic hybridization (CGH) in ameloblastomas.
- To determine if these parameters correlate with the tumor's tendency for recurrence.
Main Methods:
- Immunocytochemical staining with MIB-1 antibody on 20 ameloblastoma samples.
- Comparative genomic hybridization (CGH) performed on 17 ameloblastoma samples.
- Analysis of MIB-1 index and chromosomal aberrations over a mean follow-up of 12.4 years.
Main Results:
- All studied ameloblastomas exhibited a low MIB-1 index (range 0-2.51).
- No statistically significant correlation was found between the MIB-1 index and tumor recurrence.
- Chromosomal aberrations were detected in only 2 out of 17 cases.
Conclusions:
- The MIB-1 index is not a useful tool for predicting the clinical behavior or recurrence of ameloblastoma.
- Chromosomal imbalances appear to be infrequent in ameloblastoma.