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Helping thy neighbors: spillover at the mossy fiber glomerulus
1Department of Neurobiology, School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA.
Neuron
|August 8, 2002
Abstract:
Neurotransmitter "spillover" between neighboring synapses challenges the principle of synapse specificity. In this issue of Neuron, show that release from neighboring presynaptic sites contributes significantly to AMPA receptor-mediated postsynaptic currents at cerebellar mossy fiber synapses. Unexpectedly, spillover is predicted to improve the reliability and reduce the variability of transmission at this glomerular synapse.