Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stem cell plasticity?

Jonas Frisén1

  • 1Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE-171 77 Stockholm, Sweden. jonas.frisen@cmb.ki.se

Neuron
|August 8, 2002
PubMed
Summary
This summary is machine-generated.

Stem cell plasticity, the ability of stem cells to change lineage, is debated. While some studies suggest this phenomenon occurs, robust evidence remains elusive, questioning current biological dogma.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adult neurogenesis: New neurons, new opportunities.

Cell stem cell·2026
Same author

Computational pathology annotation enhances the resolution and interpretation of breast cancer spatial transcriptomics data.

NPJ precision oncology·2025
Same author

Identification of proliferating neural progenitors in the adult human hippocampus.

Science (New York, N.Y.)·2025
Same author

Unbiased profiling of multipotency landscapes reveals spatial modulators of clonal fate biases.

bioRxiv : the preprint server for biology·2025
Same author

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models.

Molecular oncology·2025
Same author

MEA-seqX: High-Resolution Profiling of Large-Scale Electrophysiological and Transcriptional Network Dynamics.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same journal

Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses.

Neuron·2026
Same journal

Sparse component analysis: A method that uncovers separable computations within neural population activity.

Neuron·2026
Same journal

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

Neuron·2026
Same journal

TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging.

Neuron·2026
Same journal

Image space opens up for visual neuroscience.

Neuron·2026
Same journal

Septal GLP-1 receptors control alcohol taking and seeking.

Neuron·2026
See all related articles

Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Cellular Differentiation

Background:

  • The traditional view holds that cell differentiation follows rigid, predetermined pathways.
  • Recent research has questioned this dogma, proposing stem cell plasticity as a potential mechanism for tissue regeneration and adaptation.
  • However, interpretations of existing data vary, leading to ongoing debate.

Purpose of the Study:

  • To critically evaluate the evidence for stem cell plasticity across various tissue types.
  • To determine if current findings necessitate a revision of established principles in cell differentiation.
  • To assess the reliability and reproducibility of studies suggesting lineage switching in stem cells.

Main Methods:

  • Systematic review of existing literature on stem cell differentiation and plasticity.

Related Experiment Videos

  • Analysis of experimental methodologies used in studies reporting lineage switching.
  • Comparative evaluation of data supporting and refuting stem cell plasticity.

    • Main Results:

    • Many studies reporting stem cell plasticity suffer from methodological limitations or alternative explanations.
    • Evidence for true, in vivo stem cell lineage switching remains largely inconclusive.
    • Existing data does not provide definitive proof to overturn the established model of differentiation.

    Conclusions:

    • The concept of extensive stem cell plasticity requires more rigorous and unambiguous evidence.
    • Current textbooks' descriptions of cell differentiation are likely still accurate.
    • Further research with advanced techniques is needed to definitively resolve the question of stem cell plasticity.