Jove
Visualize
Contact Us

Related Experiment Videos

Ketogenic diet: does acetone stop seizures?

Sergei S Likhodii1, W McIntyre Burnham

  • 1Department of Pharmacology and Bloorview Epilepsy Research Program, Faculty of Medicine, University of Toronto, Toronto, Canada. sergei.likhodi@utoronto.ca

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|August 8, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antiseizure effects of the cannabinoids in the amygdala-kindling model.

Epilepsia·2021
Same author

A novel allosteric modulator of the cannabinoid CB<sub>1</sub> receptor ameliorates hyperdopaminergia endophenotypes in rodent models.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2020
Same author

Benzyl alcohol suppresses seizures in two different animal models.

Neurological research·2019
Same author

Dietary Omega-3 Polyunsaturated Fatty Acid Deprivation Does Not Alter Seizure Thresholds but May Prevent the Anti-seizure Effects of Injected Docosahexaenoic Acid in Rats.

Frontiers in neurology·2019
Same author

Development of propagated discharge and behavioral arrest in hippocampal and amygdala-kindled animals.

Epilepsy research·2018
Same author

Progesterone, 5a-dihydropogesterone and allopregnanolone's effects on seizures: A review of animal and clinical studies.

Seizure·2018
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Acetone demonstrates anticonvulsant properties, potentially explaining the ketogenic diet

Area of Science:

  • Neuroscience
  • Biochemistry

Background:

  • The ketogenic diet is a treatment for refractory epilepsy, but its mechanism of action remains unclear.
  • This study investigates the hypothesis that acetone, a ketone elevated by the ketogenic diet, possesses anticonvulsant effects.

Purpose of the Study:

  • To determine if acetone has direct anticonvulsant effects.
  • To explore the impact of acute and chronic acetone administration on seizure suppression in a rat model.

Main Methods:

  • Rats received acute intraperitoneal injections of acetone (1 or 10 mmol/kg) or chronic acetone in drinking water.
  • A pentylenetetrazole seizure test was conducted 15 minutes post-injection.
  • Cerebrospinal fluid acetone concentrations were measured.

Main Results:

Related Experiment Videos

  • A 10 mmol/kg acetone injection suppressed seizures in 60% of rats (P<0.05).
  • Chronic acetone administration followed by a 1 mmol/kg injection suppressed seizures in 47% of rats (P<0.05).
  • Acute 1 mmol/kg injection alone was not significant, despite increasing cerebrospinal fluid acetone.

Conclusions:

  • Acetone exhibits anticonvulsant activity in rats.
  • Chronic acetone administration may enhance its anticonvulsant efficacy.
  • Further research is needed to link these findings to the ketogenic diet's effects and confirm relevant acetone concentrations.