Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Gastric Acid].

R Ruíz Chávez1

  • 1Facultad de Medicina Humana, UNMSM, Perú.

Revista De Gastroenterologia Del Peru : Organo Oficial De La Sociedad De Gastroenterologia Del Peru
|September 1, 1996
PubMed
Summary
This summary is machine-generated.

Gastric acid secretion, vital for homeostasis, involves complex cellular signaling pathways. Understanding these mechanisms allows for therapeutic interventions in acid-peptic diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Gastroenterologic endocrinology: basic aspects].

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru·1992
Same author

[Acute pancreatitis].

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru·1991
Same journal

[Adolescent with severe liver disease and positive autoantibodies: when Wilson's disease presents as autoimmune hepatitis].

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru·2026
Same journal

[Cholestatic jaundice revealing pylephlebitis associated with mesenteric venous thrombosis].

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru·2026
Same journal

[Severe acute pancreatitis secondary to the use of immune checkpoint inhibitors].

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru·2026
Same journal

[Exocrine pancreatic insufficiency and hyperoxaluria: a preventable renal complication from gastroenterology].

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru·2026
Same journal

[Lymphocytic esophagitis as a cause of dysphagia: a case report and brief literature review].

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru·2026
Same journal

Management of early rectal cancer with massive submucosal invasion using endoscopic intermuscular dissection: a case report.

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru·2026
See all related articles

Area of Science:

  • Physiology
  • Cell Biology
  • Gastroenterology

Background:

  • Gastric acid, secreted by parietal cells, is essential for corporal homeostasis.
  • Its production is a multi-step cellular process initiated by first messengers like histamine, acetylcholine, and gastrin.

Purpose of the Study:

  • To elucidate the cellular mechanisms regulating gastric acid secretion.
  • To explore the role of gastric acid in acid-peptic diseases.
  • To identify therapeutic targets for interfering with acid secretion.

Main Methods:

  • Review of the cellular signaling cascade involved in gastric acid production.
  • Analysis of the physiological phases of acid secretion (cephalic, gastric, intestinal).
  • Examination of factors affecting the gastro-duodenal mucosal barrier and their link to disease.

Related Experiment Videos

Main Results:

  • Gastric acid secretion is regulated by a complex interplay of receptors, second messengers (cAMP, calcium-calmodulin), and kinase-mediated protein phosphorylation.
  • The process is modulated through stimulatory (cephalic, gastric) and inhibitory (intestinal) phases.
  • Disruptions in acid secretion regulation and mucosal integrity contribute to acid-peptic diseases.

Conclusions:

  • Interference with specific steps in the cellular effector process offers therapeutic potential for managing acid secretion.
  • A thorough understanding of gastric acid physiology is crucial for developing clinical strategies for acid-peptic diseases.