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Related Experiment Videos

Continuing optic nerve atrophy following optic neuritis: a serial MRI study.

S J Hickman1, C M H Brierley, P A Brex

  • 1NMR Research Unit, Institute of Neurology, University College London, UK.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|August 9, 2002
PubMed
Summary

Optic neuritis leads to optic nerve atrophy, measurable by MRI over time. This atrophy correlates with vision loss, offering a model for studying multiple sclerosis lesions.

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Area of Science:

  • Neuroscience
  • Radiology
  • Ophthalmology

Background:

  • Multiple sclerosis (MS) is characterized by demyelinating lesions.
  • Optic neuritis is a common initial symptom of MS.
  • Atrophy in MS lesions is not well understood.

Purpose of the Study:

  • To investigate optic neuritis as a model for studying atrophy in MS lesions.
  • To assess changes in optic nerve size over time following optic neuritis.
  • To correlate optic nerve atrophy with visual function.

Main Methods:

  • Serial magnetic resonance imaging (MRI) using sTE fFLAIR sequence.
  • 10 patients with optic neuritis history underwent MRI scans 1 year apart.
  • Computer-assisted contouring measured intra-orbital optic nerve area.

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Main Results:

  • Mean optic nerve area decreased significantly (0.9 mm2, p=0.01) over 1 year.
  • Atrophy was associated with poor visual acuity.
  • Decreased visual-evoked potential (VEP) amplitude correlated with atrophy.

Conclusions:

  • Optic nerve atrophy is a feature of focal demyelinating lesions.
  • Atrophy can evolve over several years and has functional significance.
  • Optic neuritis serves as a valuable model for studying inflammatory demyelination and atrophy in MS.