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Plasmid-borne AmpC beta-lactamases.

Jan Walther-Rasmussen1, Niels Høiby

  • 1Department of Clinical Microbiology, Rigshospitalet, National University Hospital, Copenhagen, Denmark. jawalras@mail.tele.dk

Canadian Journal of Microbiology
|August 9, 2002
PubMed
Summary

Plasmid-located ampC genes, encoding class C beta-lactamases, are increasingly found in pathogenic bacteria, conferring new resistance phenotypes. This review examines their origins, spread, and properties.

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Area of Science:

  • Microbiology
  • Molecular Biology
  • Genetics

Background:

  • Historically, ampC genes were considered exclusively chromosomal.
  • Recent findings show ampC genes are increasingly plasmid-borne.
  • This shift impacts bacterial resistance profiles.

Purpose of the Study:

  • To review the phylogenetic origins of plasmid-encoded AmpC beta-lactamases.
  • To discuss their occurrence and mechanisms of spread.
  • To analyze their hydrolytic properties.

Main Methods:

  • Literature review of studies on ampC genes and beta-lactamases.
  • Analysis of phylogenetic data.
  • Examination of resistance phenotypes conferred by plasmid-borne ampC genes.

Main Results:

  • Plasmid-mediated ampC genes have emerged as a significant factor in bacterial resistance.
  • These genes are acquired by ampC-deficient bacteria, leading to new resistance phenotypes.
  • The review covers the evolutionary history and dissemination pathways.

Conclusions:

  • Plasmid-encoded AmpC beta-lactamases represent a growing challenge in antimicrobial resistance.
  • Understanding their spread and properties is crucial for combating infections.
  • Further research into their hydrolytic capabilities and evolutionary trajectory is warranted.

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