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Mitomycin-C induced hemolytic uremic syndrome: a case report
Rajaram K Gundappa1, Kamal Sud, Harbir S Kohli
1Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Renal Failure
|August 9, 2002
Abstract:
Mitomycin-C is used widely in the treatment of malignancies and is associated with serious dose related adverse effects including the occurrence of hemolytic uremic syndrome. We report a patient with a colonic adenocarcinoma who developed hemolytic uremic syndrome after receiving 85 mg/m2 of the drug. The patient was left untreated and died 5 months after this diagnosis was made, of a second malignancy. Differential diagnosis and treatment of this condition are discussed.