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Related Experiment Videos

Third molar agenesis in Down syndrome.

Jens Fog Lomholt1, Björn G Russell, Kaj Stoltze

  • 1Department of Orthodontics, School of Dentistry, Faculty of Health Sciences, University of Copenhagen, Denmark.

Acta Odontologica Scandinavica
|August 9, 2002
PubMed
Summary

Individuals with Down syndrome exhibit a significantly higher prevalence of third molar agenesis, occurring approximately four times more frequently than in the general population. This dental anomaly is more common in the maxilla than the mandible.

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Area of Science:

  • Genetics
  • Odontology
  • Human Biology

Background:

  • Third molar agenesis is a common dental anomaly.
  • Down syndrome is associated with various developmental abnormalities.
  • Understanding dental anomalies in Down syndrome can provide insights into genotype-phenotype interactions.

Purpose of the Study:

  • To investigate the frequency and patterns of third molar agenesis in individuals with Down syndrome.
  • To compare the occurrence of third molar agenesis in Down syndrome individuals with normal Caucasian populations.
  • To explore the distribution of agenesis between the maxilla and mandible and by gender.

Main Methods:

  • Radiological examination of a Danish cohort of individuals with Down syndrome (39 female, 31 male).
  • Comparison with two control groups of normal Caucasian populations.

Related Experiment Videos

  • Analysis of frequency, gender distribution, and maxillary/mandibular occurrence of third molar agenesis.

    • Main Results:

    • Third molar agenesis occurred approximately four times more frequently in Down syndrome individuals compared to the normal population.
    • Agenesis was more prevalent in the maxilla than in the mandible.
    • The frequency of agenesis did not differ significantly between males and females.

    Conclusions:

    • Third molar agenesis is significantly elevated in individuals with Down syndrome.
    • Dental germ development is crucial for understanding Down syndrome phenotypes.
    • Studying tooth agenesis aids in comprehending genotype-phenotype interactions in developmental disorders.