6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity

Serine Acetyltransferase from Pseudomonas aeruginosa: Distinctive Features, Pleiotropic Roles, and Therapeutic Potential.

International journal of molecular sciences·2026

Antibacterial and antibiofilm activity of a triterpenoid-rich Eucalyptus globulus leaf extract against gram-positive bacteria.

Scientific reports·2026

Development of Biphenyl-Substituted Uracil-Based Hydroxamic Acids (UBHAs) as Potent HDAC Inhibitors with Pro-Apoptotic Activity in Leukemia and Prostate Cancer Cells.

Journal of medicinal chemistry·2026

Structure-Based Discovery of Obeticholic Acid Derivatives as Novel Farnesoid X Receptor Partial Agonists with Improved Selectivity and Reduced Off-Target Effects.

ChemMedChem·2026

Benzotriazole derivatives as alternate O-acetylserine sulfhydrylase substrates to impair cysteine biosynthesis in gram-negative bacteria.

iScience·2025

Initial Development of Automated Machine Learning-Assisted Prediction Tools for Aryl Hydrocarbon Receptor Activators.

Pharmaceutics·2024

A 177Lu-Labeled Circular Bivalent Aptamer for PTK7-Targeting Radionuclide Therapy in Ovarian Cancer and Orthotopic Hepatoblastoma.

Journal of medicinal chemistry·2026

From Fragment Hit to Clinical Candidate: Discovery of Dual H1R/H4R Ligands with Superior Efficacy in Allergic Conjunctivitis.

Journal of medicinal chemistry·2026

Potent Anticancer Tethered Organorhodium(III) Complexes Target the Mitochondria.

Journal of medicinal chemistry·2026

Discovery of a Covalent NLRP3 LRR-Domain Probe: Reversing Renal Fibrosis via Immunometabolic Reprogramming in Organoid and Murine Models.

Journal of medicinal chemistry·2026

Lead Optimization of Multimutant KRAS Switch-II Pocket Macrocyclic Inhibitors via Isosteric Replacement to Improve ADME and Oral Exposure.

Journal of medicinal chemistry·2026

Synthesis, Biological Evaluation, and Biodistribution of Xinyne, a Novel Quinazoline-carbazole N-methylamine Anticancer Agent Used in Mice Xenograft Models.

Journal of medicinal chemistry·2026

Challenges and opportunities for the construction of the next IntCal and SHCal radiocarbon calibration curves.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026

"Green spectrophotometric determination of rupatadine, its toxic impurity, and methyl paraben: comparative AI-assisted univariate versus multivariate chemometrics".

Scientific reports·2026

Influence of sample size, content range, and sample removal on slope and bias correction in Fourier-transform mid-infrared spectroscopy for milk fatty acids.

Journal of dairy science·2026

Characterizing the Elemental Metabolome in Asparagus officinalis with Multielemental Speciation Analysis.

Journal of agricultural and food chemistry·2026

Analysis of ultra short-chain PFAS in urine: method development by LC-MS/MS and first human biomonitoring results from the German National Cohort (NAKO).

Environment international·2026

An accurate and sensitive method for identifying atmospheric alkylamines: selective enrichment by alkaline purging-acidic absorption coupled with ion chromatography-tandem mass spectrometry.

Journal of chromatography. A·2026

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6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic

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Serine Acetyltransferase from Pseudomonas aeruginosa: Distinctive Features, Pleiotropic Roles, and Therapeutic Potential.

Antibacterial and antibiofilm activity of a triterpenoid-rich Eucalyptus globulus leaf extract against gram-positive bacteria.

Development of Biphenyl-Substituted Uracil-Based Hydroxamic Acids (UBHAs) as Potent HDAC Inhibitors with Pro-Apoptotic Activity in Leukemia and Prostate Cancer Cells.

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"Green spectrophotometric determination of rupatadine, its toxic impurity, and methyl paraben: comparative AI-assisted univariate versus multivariate chemometrics".

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Characterizing the Elemental Metabolome in Asparagus officinalis with Multielemental Speciation Analysis.

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Related Experiment Videos

6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic...

Abstract:

Related Concept Videos

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6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic