Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bacteriophages: evolution of the majority.

Roger W Hendrix1

  • 1Pittsburgh Bacteriophage Institute & Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260, USA. rhx@pitt.edu

Theoretical Population Biology
|August 9, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hybrid Vigor: Importance of Hybrid λ Phages in Early Insights in Molecular Biology.

Microbiology and molecular biology reviews : MMBR·2022
Same author

Structural basis of DNA packaging by a ring-type ATPase from an archetypal viral system.

Nucleic acids research·2022
Same author

Complete Genome Sequences of Lambdoid Phages 21, 434, and 434B and Several Lambda Hybrids.

Microbiology resource announcements·2022
Same author

Genome analysis of Salmonella enterica serovar Typhimurium bacteriophage L, indicator for StySA (StyLT2III) restriction-modification system action.

G3 (Bethesda, Md.)·2021
Same author

DNA Packaging and Genomics of the <i>Salmonella</i> 9NA-Like Phages.

Journal of virology·2019
Same author

Capsids and Genomes of Jumbo-Sized Bacteriophages Reveal the Evolutionary Reach of the HK97 Fold.

mBio·2017

Double-stranded DNA-tailed bacteriophages are ancient, rapidly evolving viruses. Their evolution is driven by horizontal gene transfer and recombination, leading to new gene acquisition and functional assembly.

Area of Science:

  • Microbiology
  • Virology
  • Evolutionary Biology

Background:

  • Double-stranded DNA-tailed bacteriophages represent a vast and ancient group of viruses.
  • Their evolutionary dynamics are central to understanding viral diversity and adaptation.
  • Bacteriophages exhibit potential ancestral links to eukaryotic and archaeal viruses.

Purpose of the Study:

  • To investigate the evolutionary mechanisms of dsDNA-tailed bacteriophages.
  • To elucidate the role of horizontal gene transfer in phage genome evolution.
  • To explore the origins and assembly of novel phage genes.

Main Methods:

  • Comparative genomic analysis of bacteriophage genomes.
  • Examination of recombination patterns (non-homologous and homologous).

Related Experiment Videos

  • Inference of gene acquisition and assembly mechanisms.

    • Main Results:

    • Horizontal sequence exchange is a key driver of bacteriophage evolution.
    • Non-homologous recombination facilitates sequence acquisition, while homologous recombination reassorts variants.
    • Mechanisms for adding new genes and assembling novel functions from existing parts were identified.
    • Sequence exchange occurs frequently among related phages and globally at lower frequencies.

    Conclusions:

    • dsDNA-tailed bacteriophages evolve through extensive horizontal gene transfer and recombination.
    • These processes enable rapid adaptation and the generation of functional novelty.
    • The evolutionary strategies of phages may inform our understanding of viral origins and interactions.