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Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
Diagnosing diastolic heart failure
D J W van Kraaij1, P E J van Pol, A W Ruiters
1Department of Cardiology, Academic Medical Hospital Maastricht, P.O. Box 5800, 6262 AZ, The Netherlands. dvankraaij@hotmail.com
Insights
Left ventricular diastolic dysfunction is a key cause of heart failure. Echocardiography is the primary diagnostic tool, but future strategies require further development and inclusion in clinical trials.
Area of Science:
- Cardiology
- Heart Failure Research
Background:
- Left ventricular diastolic dysfunction is increasingly recognized as a significant cause of heart failure.
- It affects up to 40% of patients with congestive heart failure.
Purpose of the Study:
- To review the pathophysiology of left ventricular diastolic dysfunction and diastolic heart failure.
- To outline current diagnostic methods for these conditions.
Main Methods:
- Review of existing literature on diastolic dysfunction and heart failure.
- Discussion of diagnostic techniques including invasive hemodynamics, exercise testing, echocardiography, and MRI.
Main Results:
- Invasive hemodynamic measurements are the gold standard for diagnosing LV diastolic dysfunction.
- Echocardiography is the most accessible and widely used method for diagnosing diastolic heart failure.
- MRI shows potential for noninvasive assessment but requires further validation and has limited current application.
Conclusions:
- Optimal diagnostic and therapeutic strategies for diastolic heart failure need further development.
- Future heart failure trials must include detailed assessments of left ventricular systolic and diastolic function.
Background:
increasing evidence supports the existence of left ventricular diastolic dysfunction as an important cause of congestive heart failure, present in up to 40% of heart failure patients.
Aim:
to review the pathophysiology of LV diastolic dysfunction and diastolic heart failure and the currently available methods to diagnose these disorders.
Results:
for diagnosing LV diastolic dysfunction, invasive hemodynamic measurements are the gold standard. Additional exercise testing with assessment of LV volumes and pressures may be of help in detecting exercise-induced elevation of filling pressures because of diastolic dysfunction. However, echocardiography is obtained more easily, and will remain the most often used method for diagnosing diastolic heart failure in the coming years. MRI may provide noninvasive determination of LV three-dimensional motion during diastole, but data on correlation of MRI data with clinical findings are scant, and possibilities for widespread application are limited at this moment.
Conclusions:
in the forthcoming years, optimal diagnostic and therapeutic strategies for patients with primary diastolic heart failure have to be developed. Therefore, future heart failure trials should incorporate patients with diastolic heart failure, describing precise details of LV systolic and diastolic function in their study populations.
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