A comparison of human G-Csf and human Gm-Csf given concurrently with anti-cancer chemotherapy

Granulocyte-colony-stimulating factor (G-Csf) and granulocyte-macrophagecolony-stimulating factor (GM-Csf) were each given concurrently with continuous infusion of doxorubicin, ifosphamide, or vinorelbine. Both cytokines enabled the dose intensity of these three anti-tumor agents to be substantially increased without an increase in drug toxicity. The effect of Gm-Csf as a stimulant of dendritic cell production and function was noted.