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Related Experiment Videos

Biologically active steroidal glycosides from Tribulus terrestris.

E Bedir1, I A Khan, L A Walker

  • 1National Center for Natural Products Research, University of Mississippi, USA.

Die Pharmazie
|August 10, 2002
PubMed
Summary

Steroidal saponins from Tribulus terrestris show potent antimicrobial and anticancer activity. Spirostanol compounds demonstrated significant effects against fungi and various cancer cell lines, unlike furostanol derivatives.

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Area of Science:

  • Natural Products Chemistry
  • Pharmacology
  • Medicinal Chemistry

Background:

  • Tribulus terrestris is a plant used in traditional medicine.
  • Steroidal saponins are bioactive compounds found in plants.
  • Investigating natural products for therapeutic potential is crucial.

Purpose of the Study:

  • To evaluate the antimicrobial and cytotoxic effects of steroidal saponins from Tribulus terrestris.
  • To identify specific structural features responsible for bioactivity.

Main Methods:

  • Isolation and purification of steroidal saponins from Tribulus terrestris.
  • Antimicrobial assays against Candida albicans and Cryptococcus neoformans.
  • Cytotoxicity assays against human cancer cell lines (SK-MEL, KB, BT-549, SK-OV-3).

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Main Results:

  • Spirostanol saponins (compounds 1-3) showed significant antifungal and anticancer activity.
  • Furostanol saponins (compounds 4-7) exhibited no activity.
  • Compound 3 displayed broad-spectrum anticancer activity with IC50 values ranging from 6.0 to 8.2 µg/mL.
  • Compounds 1 and 2 showed selective cytotoxicity against SK-MEL (IC50s 6.7 and 9.1 µg/mL).
  • MIC values for antifungal activity ranged from 1.5 to 6.2 µg/mL for compounds 1-3.

Conclusions:

  • Spirostanol-based steroidal saponins from Tribulus terrestris possess significant antimicrobial and cytotoxic properties.
  • Specific structural features of spirostanol glycosides are essential for their observed bioactivities.
  • These findings highlight the therapeutic potential of Tribulus terrestris saponins in combating fungal infections and cancer.