Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Frontotemporal dementia.

Andrew Kertesz¹, David G Munoz

¹Department of Clinical Neurological Sciences, St. Joseph's Hospital, University of Western Ontario, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada. andrew.kertesz@sjhc.london.on.ca

The Medical Clinics of North America

|August 10, 2002

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Aspergillus-Infiltrated Optic Nerve Sheath Meningioma in Immunocompetent Host Mimicking Optic Neuritis.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2026

Same author

A multimodal evaluation of transcranial photobiomodulation in mild cognitive impairment: Cognitive, metabolic, and neuroimaging outcomes of a pilot randomized controlled trial.

Journal of Alzheimer's disease : JAD·2026

Same author

Reviewer Comment on Pejhan et al. "Clinical relevance, and prognostic significance of isolated angiitis of the vasa vasorum in temporal artery biopsies".

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026

Same author

Genetic and Hormonal Contributions to Psychosis Symptoms in Alzheimer's Disease: A Sex-Stratified Analysis.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2026

Same author

A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions.

Nature genetics·2026

Same author

Peripheral Blood Epigenetic Age Acceleration is Associated With Psychosis in Female APOE4 Carriers With Mild Cognitive Impairment and Alzheimer's Disease: A Pilot Study.

Journal of geriatric psychiatry and neurology·2026

Same journal

Care Transitions Continue to Evolve.

The Medical clinics of North America·2026

Same journal

Navigating the Gaps: A Comprehensive Overview of Care Transitions Across the Continuum.

The Medical clinics of North America·2026

Same journal

Care Transitions and Value-Based Payment Models in the United States.

The Medical clinics of North America·2026

Same journal

Technology and Innovation in Care Transitions: Imagining the Future of Postdischarge Care.

The Medical clinics of North America·2026

Same journal

Primary Care, Specialists, and Hospitals: Bridging the Gaps in Communication and Coordination.

The Medical clinics of North America·2026

Same journal

Social Determinants of Health: Unique Considerations in Transitions of Care.

The Medical clinics of North America·2026

See all related articles

Frontotemporal dementia (FTD), formerly Pick's disease, is often underdiagnosed due to its varied presentation. This review highlights the overlap and distinct features of FTD subtypes, aiding in better recognition.

Area of Science:

Neurology
Neuroscience
Pathology

Background:

Frontotemporal dementia (FTD) is the current term for clinical Pick's disease.
The term Pick's disease (PiD) is now primarily used for the pathological variant characterized by Pick bodies.
FTD is frequently underdiagnosed and underestimated, often due to the separate consideration of its complex components.

Purpose of the Study:

To describe the clinical presentation, pathology, and genetic mechanisms of frontotemporal dementia.
To emphasize the significant overlap and distinctive features among different FTD subtypes.
To address the misleading perception of heterogeneity in FTD descriptions.

Main Methods:

Review of clinical, pathological, and genetic literature on frontotemporal dementia.

Related Experiment Videos

Analysis of diagnostic criteria and clinical manifestations.

Comparative study of FTD subtypes, focusing on shared and unique characteristics.

Main Results:

FTD encompasses a spectrum of clinical and pathological presentations.
There is substantial overlap between the various forms of FTD, challenging distinct classification.
Specific features differentiate the subtypes despite the overall heterogeneity.

Conclusions:

A comprehensive understanding of FTD requires recognizing both its overlapping features and individual distinctions.
Improved diagnostic awareness and a holistic approach are crucial for addressing the underdiagnosis of FTD.
Further research into the genetic mechanisms and distinct pathological pathways is warranted.