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[Hemostasis suppression by a combination of heparin and acetylsalicylic acid]

D Wamhoff, H Schmechel

    Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
    |September 15, 1975
    PubMed

    The effect of a combined application of acetylsalicylic acid and heparin on haemostasis is examined on 7 healthy test persons. Apart from the change of the plasmatic coagulation and the platelet function by the pharmaca a prolongation of the bleeding time which is larger than the values of the individual application can be established. In the in-vitro-experiment could be proved that the prolonged bleeding time is based on the prevented by acetylsalicylic acid release of the heparin neutralising factor 4 from the platelets. An improvement of the therapeutic effect of heparin when at the same time acetylsalicylic acid is given is discussed.

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