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Updated: Aug 8, 2026

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Transdifferentiation, a Potential Mechanism for Covering Vascular Grafts Grown Within Recipient's Peritoneal Cavity

N I Moldovan, K Havemann

    Circulation Research
    |August 10, 2002
    PubMed
    Abstract

    No abstract available in PubMed .

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    Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
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