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Related Experiment Videos

Blastomycosis and pregnancy.

Luciano B Lemos1, Mahdia Soofi, Emran Amir

  • 1Department of Pathology, University of Mississippi Medical Center, Jackson, USA.

Annals of Diagnostic Pathology
|August 10, 2002
PubMed
Summary

Blastomycosis during pregnancy is rare but serious. Fetal outcomes are more concerning than maternal outcomes, with a 10% fetal infection rate and no maternal deaths reported in this study.

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Area of Science:

  • Medical Mycology
  • Obstetrics and Gynecology
  • Infectious Diseases

Background:

  • Blastomycosis is a rare fungal infection, particularly during pregnancy.
  • Mississippi has the highest prevalence of blastomycosis in North America.
  • Pregnancy involves partial immunodepression, increasing susceptibility to opportunistic infections like blastomycosis.

Purpose of the Study:

  • To analyze the impact of blastomycosis on pregnancy.
  • To assess maternal and fetal risks associated with blastomycosis during gestation.
  • To review treatment and outcomes of blastomycosis in pregnant patients.

Main Methods:

  • Case series review of three pregnancies complicated by blastomycosis at the University of Mississippi Medical Center.
  • Analysis of 16 additional published cases of blastomycosis in pregnancy.
  • Comparison of maternal and fetal outcomes, including infection rates, mortality, and disease progression.

Main Results:

  • Fetal risk appears to exceed maternal risk in blastomycosis during pregnancy.
  • Two out of 20 (10%) infants had transplacental blastomycosis infection, and both died.
  • No maternal deaths were reported; 14 mothers achieved complete cure, and four had postpartum regression. Untreated mothers also showed improvement post-delivery.

Conclusions:

  • Blastomycosis in pregnancy requires prompt recognition and treatment to improve maternal and fetal outcomes.
  • While fetal mortality is a significant concern, maternal prognosis is generally favorable with appropriate management or even spontaneously post-delivery.
  • The study highlights the importance of vigilance for blastomycosis in obstetric settings, especially in high-prevalence regions.

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