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A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
[A linkage analysis of quantitative trait loci for familial schizophrenia on chromosome 1]
Guiqing Cai1, Xinyao Wu, Tao Li
1Department of Forensic Medicine, Zhongshan Medical College Sun Yat-Sen University, Guangzhou, Guangdong, 510080 P.R. China. caiguiqing@163.com
Objective:
To explore the molecular genetic relationship between chromosome 1 and quantitative trait loci for familial schizophrenia.
Methods:
A series of assessment scales included positive and negative syndrome scale (PANSS), global assessment of functional scale (GAFS), premorbid schizoid and schizotypal traits scale (PSST), premorbid social adjustment scale (PSA) were applied to quantify the phenotypes of schizophrenia. Non-parametric linkage analysis of quantitative traits was conducted in 32 multiplex pedigrees with schizophrenia by using 29 microsatellite makers on chromosome 1.
Results:
Haseman-Elston quantitative trait analysis detected a maximum Traditional H-E Lods of 1.73 and a maximum EH H-E Lods of 1.65 of negative symptoms (PANSS-N ) at 147.64 cM, which was overlapped to the positive region of 1q21-23 in qualitative linkage analysis.
Conclusion:
The results suggest there might be an independent quantitative trait locus of negative symptoms on 1q21-23 for familial schizophrenia.
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