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[A study of the relationship between MICA gene and systemic lupus erythematosus]
Guihong Ban1, Jiayou Chu, Changzhi Mao
1Department of Genetics, Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, Yunnan, 650118 P.R. China. chujy@public.km.yn.cn
Objective:
To investigate the relationship between major histocompatibility complex class I chain-related A(MICA) gene and systemic lupus erythematosus (SLE).
Methods:
The alleles and frequencies of exons 4 and 5 of MICA gene were determined in 70 cases of SLE and 152 controls of Yunnan Hans by STR genotyping, polymerase chain reaction, single strand conformation polymorphism and bidirection DNA sequencing.
Results:
Five alleles of exon 5 and 10 alleles of exon 4 were found in this study. The frequency of each allele was determined in patients and controls. There was no significant difference between the two groups in exons 4 and 5 of MICA gene.
Conclusion:
Exons 4 and 5 of MICA were not related to SLE in Yunnan Hans.